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FIGURE 2 Many alterations in insulin associated mechanisms in the kidney are driven by insulin resistance (IR), leading to diabetic nephropathy if not reestablished (Svensson and Eriksson, 2006)

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Notably, the TCA cycle intermediate -KG can facilitate DNA demethylation and epigenetic reprogramming, indicating a potential role of metabolism in fate specification [262]

however, these organs also utilize the machinery for salvage

To identify key binding residues, we performed alanine-scanning mutagenesis across BPC157